Factor Vill/von Willebrand Factor Binding to von Willebrand’s Disease Platelets
نویسندگان
چکیده
A form of von Willebrand’s disease has been described with enhanced ristocetin-induced platelet aggregation and anodal migration of the factor VIll/von Willebrand factor protein (type lIb). We studied two families with this form of von Willebrand s disease and macrothrombocytopenia. We have found that these platelets bind more of the normal and intermediate-sized multimers of the factor VIll/von Willebrand factor than normal platelets. Analysis of the
منابع مشابه
Effect of the Multimeric Structure of the Factor Vill/von Willebrand Factor Protein on Binding to Platelets
The characteristics of the intact factor VIll/von Willebrand factor protein binding to human platelets was compared to 2-mercaptoethanol-treated factor VIll/von Willebrand factor protein and to fractions of plasma factor VIll/von Willebrand factor protein that elute after the void volume. These studies indicate that the factor VIlI/von Willebrand factor protein larger size oligomers bind prefer...
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